The result was consistent with the semiconservative replication hypothesis.
2.
If left unrepaired, AP sites can lead to mutation during semiconservative replication.
3.
DNA replication initially produces two catenated or linked circular DNA duplexes, each comprising one parental strand and one newly synthesised strand ( by nature of semiconservative replication ).
4.
SDSA is unique in that D-loop translocation results in conservative rather than semiconservative replication, as the first extended strand is displaced from its template strand, leaving the homologous duplex intact.
5.
Semiconservative replication would result in double-stranded DNA with one strand of 15 N DNA, and one of 14 N DNA, while dispersive replication would result in double-stranded DNA with both strands having mixtures of 15 N and 14 N DNA, either of which would have appeared as DNA of an intermediate density.
6.
In their famous paper " Molecular structure of Nucleic Acids ", Watson and Crick noted coyly, " It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material . " After the 1958 Meselson Stahl experiment confirmed the semiconservative replication of DNA, it was clear to most biologists that nucleic acid sequence must somehow determine Khorana.
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